Hydrochloric Acid → Icotinib hydrochloride

HRID 1526523Notes

Reaction equation

HRID 1526523 reaction equation
[CH:1]#[C:2][C:3]1[CH:4]=[CH:5][CH:6]=[C:7]([NH:9][C:10]2[N:19]=[CH:18][N:17]=[C:16]3[C:11]=2[CH:12]=[C:13]2[O:29][CH2:28][CH2:27][O:26][CH2:25][CH2:24][O:23][CH2:22][CH2:21][O:20][C:14]2=[CH:15]3)[CH:8]=1.[ClH:30]>C(O)C>[CH:1]#[C:2][C:3]1[CH:4]=[CH:5][CH:6]=[C:7]([NH:9][C:10]2[C:11]3[C:16](=[CH:15][C:14]4[O:20][CH2:21][CH2:22][O:23][CH2:24][CH2:25][O:26][CH2:27][CH2:28][O:29][C:13]=4[CH:12]=3)[N:17]=[CH:18][N:19]=2)[CH:8]=1.[ClH:30]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 22024915Icotinib

Product 1

HCID 44609731Icotinib hydrochloride

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

Icotinib (500 mg) was added into 100 mL of reaction flask and dissolved with 30 mL of ethanol. Hydrogen chloride gas was added while stirring. After its completion, the reaction mixture was filtered to give crude product. The crude product was further purified by recrystallization with isopropyl alcohol to give Icotinib hydrochloride (515 mg).

Workup

  1. filtrationAfter its completion, the reaction mixture was filtered
  2. customto give crude product
  3. customThe crude product was further purified by recrystallization with isopropyl alcohol

Sources & evidence

ORD record
ord-80da284135314baea98d6d3c9585b5af
Source dataset
uspto-grants-2015_07
Patent number
US09085588B2

Reaction notes

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