Pyridine → HCID 85615786, compound

HRID 1527192Notes

Reaction equation

HRID 1527192 reaction equation
[Br:1][CH2:2][C:3]([O:5][CH2:6][C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=1)=[O:4].[N:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1>CC(C)=O>[Br-:1].[CH2:6]([O:5][C:3]([CH2:2][N+:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1)=[O:4])[C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=1

Participants

4

Reactant 2

HCID 1049PyridineHCID 62576Benzyl bromoacetate

Product 1

HCID 85615786HCID 85615786, compound

Reagents, catalysts & solvents 1

HCID 180AcetoneSolvent2×

Conditions

Temperature
60 °C

Procedure

To a solution of benzyl bromoacetate (10 g, 43.7 mmol) in acetone (200 mL) was added a solution of pyridine (3.51 mL, 43.7 mmol) in acetone (20 mL) and the resulting mixture was stirred at 60° C. under nitrogen over the week-end. Then allowed to cool to RT and concentrated to give the desired material. MS (LC/MS): 228.1 [MH]+.

Workup

  1. temperatureto cool to RT
  2. concentrationconcentrated

Sources & evidence

ORD record
ord-9c6eeac9948e41bfac2e9a2d61ae7571
Source dataset
uspto-grants-2015_07
Patent number
US09085555B2

Reaction notes

Loading…