(1-Carbamoyl-1H-indol-3-yl)-acetic acid → (1-Carbamoyl-2-methyl-1H-indol-3-yl)-acetic acid

HRID 1527199노트

반응식

HRID 1527199 반응식
C(N1C2C(=CC=CC=2)C(CC(O)=O)=C1)(=O)N.C([O:19][C:20](=[O:35])[CH2:21][C:22]1[C:30]2[C:25](=[CH:26][CH:27]=[CH:28][CH:29]=2)[N:24]([C:31](=[O:33])[NH2:32])[C:23]=1[CH3:34])C>>[C:31]([N:24]1[C:25]2[C:30](=[CH:29][CH:28]=[CH:27][CH:26]=2)[C:22]([CH2:21][C:20]([OH:35])=[O:19])=[C:23]1[CH3:34])(=[O:33])[NH2:32]

참가 물질

3

반응물 2

HCID 68283440(1-Carbamoyl-1H-indol-3-yl)-acetic acidHCID 68283853(1-carbamoyl-2-methyl-1H-indol-3-yl)-acetic acid ethyl ester

생성물 1

HCID 68283651(1-Carbamoyl-2-methyl-1H-indol-3-yl)-acetic acid

실험 절차

was prepared in a similar manner as described in Scheme A8 Step B for (1-carbamoyl-1H-indol-3-yl)-acetic acid starting from (1-carbamoyl-2-methyl-1H-indol-3-yl)-acetic acid ethyl ester. The crude product (brownish solid) obtained after extractive work-up was used directly in the next step without purification. MS: 233 [M+H]+; tR (HPLC conditions b) 3.26 min.

후처리

  1. customwas prepared in a similar manner

출처 및 근거

ORD 기록
ord-7b80917c3ce84bc49582c0dbcecfb519
출처 데이터셋
uspto-grants-2015_07
특허 번호
US09085555B2

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