3-(Trifluoroacetyl)indole → [3-(trifluoroacetyl)-1H-indol-1-yl]acetic acid

HRID 1527240Notes

Reaction equation

HRID 1527240 reaction equation
[F:1][C:2]([F:15])([F:14])[C:3]([C:5]1[C:13]2[C:8](=[CH:9][CH:10]=[CH:11][CH:12]=2)[NH:7][CH:6]=1)=[O:4].C(C1C2C(=CC=C(OC(F)(F)F)C=2)N([CH2:33][C:34]([OH:36])=[O:35])C=1)(=O)C>>[F:15][C:2]([F:1])([F:14])[C:3]([C:5]1[C:13]2[C:8](=[CH:9][CH:10]=[CH:11][CH:12]=2)[N:7]([CH2:33][C:34]([OH:36])=[O:35])[CH:6]=1)=[O:4]

Participants

3

Reactant 2

HCID 5891263-(Trifluoroacetyl)indoleHCID 68284505(3-Acetyl-5-trifluoromethoxy-indol-1-yl)acetic acid

Product 1

HCID 3154371[3-(trifluoroacetyl)-1H-indol-1-yl]acetic acid

Procedure

was prepared from 2,2,2-trifluoro-1-(1H-indol-3-yl)-ethanone in a similar manner as described in Scheme A13 (step B and C) for the preparation of (3-acetyl-5-trifluoromethoxy-indol-1-yl)-acetic acid. White solid. MS: 272.0 [M+H]+; tR (HPLC conditions c): 4.59 min.

Workup

  1. custom4.59 min.

Sources & evidence

ORD record
ord-603c5d4f58aa4b7bae41576d74402e75
Source dataset
uspto-grants-2015_07
Patent number
US09085555B2

Reaction notes

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