Indole → HCID 71009703, compound

HRID 1527242Notes

Reaction equation

HRID 1527242 reaction equation
N1C2C(=CC=CC=2)C=C1.[CH3:10][O:11][CH2:12][C:13](Cl)=[O:14].C([C:19]1[C:27]2[C:22](=[CH:23][CH:24]=[C:25](OC(F)(F)F)[CH:26]=2)[N:21]([CH2:33][C:34]([OH:36])=[O:35])[CH:20]=1)(=O)C>>[CH3:10][O:11][CH2:12][C:13]([C:19]1[C:27]2[C:22](=[CH:23][CH:24]=[CH:25][CH:26]=2)[N:21]([CH2:33][C:34]([OH:36])=[O:35])[CH:20]=1)=[O:14]

Participants

4

Reactant 3

HCID 798IndoleHCID 96623Methoxyacetyl chlorideHCID 68284505(3-Acetyl-5-trifluoromethoxy-indol-1-yl)acetic acid

Product 1

HCID 71009703HCID 71009703, compound

Procedure

was prepared from 1H-indole in a similar manner as described in Scheme A13 (in step A, 2-methoxyacetyl chloride was used instead of acetyl chloride) for the preparation of (3-acetyl-5-trifluoromethoxy-indol-1-yl)-acetic acid. Brown solid. MS: 248.0 [M+H]+; tR (HPLC conditions c): 3.42 min.

Workup

  1. custom3.42 min.

Sources & evidence

ORD record
ord-f00e7c04f2b4449b8e8e874db2295daf
Source dataset
uspto-grants-2015_07
Patent number
US09085555B2

Reaction notes

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