Trifluoroacetic acid → HCID 68284012, compound

HRID 1527256Notes

Reaction equation

HRID 1527256 reaction equation
C([O:5][C:6](=[O:20])[CH2:7][N:8]1[C:12]2[N:13]=[CH:14][N:15]=[CH:16][C:11]=2[C:10]([C:17](=[O:19])[CH3:18])=[CH:9]1)(C)(C)C.C(O)(C(F)(F)F)=O>C(Cl)Cl>[C:17]([C:10]1[C:11]2[CH:16]=[N:15][CH:14]=[N:13][C:12]=2[N:8]([CH2:7][C:6]([OH:20])=[O:5])[CH:9]=1)(=[O:19])[CH3:18]

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 68283796HCID 68283796, compound

Product 1

HCID 68284012HCID 68284012, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

A solution of (5-acetyl-pyrrolo[2,3-d]pyrimidin-7-yl)-acetic acid tert-butyl ester (146 mg, 0.53 mmol) and TFA (0.814 mL, 10.62 mmol) in CH2Cl2 (2.5 mL) was stirred at RT for 24 h. Solvents were removed under reduced pressure and the material thus obtained was used without further purification in the next step. 1H-NMR (400 MHz, DMSO): δ (ppm): 9.45 (s, 1H), 9.0 (s, 1H), 8.68 (s, 1H), 7.66-7.56 (m, 2H), 5.16 (s, 2H), 2.53 (s, 3H).

Workup

  1. customSolvents were removed under reduced pressure
  2. customthe material thus obtained
  3. customwas used without further purification in the next step

Sources & evidence

ORD record
ord-08496146c2534a20bda64b0f1f208b9f
Source dataset
uspto-grants-2015_07
Patent number
US09085555B2

Reaction notes

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