Trifluoroacetic acid → 1386457-64-2

HRID 1527287Notes

Reaction equation

HRID 1527287 reaction equation
[C:1]([C:4]1[C:12]2[C:7](=[CH:8][CH:9]=[CH:10][CH:11]=2)[N:6]([CH2:13][C:14]([O:16]C(C)(C)C)=[O:15])[N:5]=1)(=[O:3])[NH2:2].C(O)(C(F)(F)F)=O>C(Cl)Cl>[C:1]([C:4]1[C:12]2[C:7](=[CH:8][CH:9]=[CH:10][CH:11]=2)[N:6]([CH2:13][C:14]([OH:16])=[O:15])[N:5]=1)(=[O:3])[NH2:2]

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 68283122Tert-butyl 2-(3-carbamoyl-1H-indazol-1-yl)acetate

Product 1

HCID 682833421386457-64-2

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To a solution of tert-butyl 2-(3-carbamoyl-1H-indazol-1-yl)acetate (3.42 g, 12.4 mmol) in CH2Cl2 (20 mL) was added TFA (10 mL, 130 mmol) and the resulting mixture was stirred at RT for 16 h. The reaction mixture was concentrated in vacuo, the residual solid was suspended in methanol and concentrated again in vacuo to give the title compound. MS (LC/MS): 220 [M+H]+; tR (HPLC conditions k): 1.79 min.

Workup

  1. concentrationThe reaction mixture was concentrated in vacuo
  2. concentrationconcentrated again in vacuo

Sources & evidence

ORD record
ord-3a891d8fc85a4806af6de6af68923fb9
Source dataset
uspto-grants-2015_07
Patent number
US09085555B2

Reaction notes

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