Trifluoroacetic acid → 1H-Pyrazolo[3,4-c]pyridine-1-acetic acid, 3-(aminocarbonyl)-

HRID 1527291Notes

Reaction equation

HRID 1527291 reaction equation
[C:1]([C:4]1[C:12]2[C:7](=[CH:8][N:9]=[CH:10][CH:11]=2)[N:6]([CH2:13][C:14]([O:16]C(C)(C)C)=[O:15])[N:5]=1)(=[O:3])[NH2:2].C(O)(C(F)(F)F)=O>C(Cl)Cl>[C:1]([C:4]1[C:12]2[C:7](=[CH:8][N:9]=[CH:10][CH:11]=2)[N:6]([CH2:13][C:14]([OH:16])=[O:15])[N:5]=1)(=[O:3])[NH2:2]

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 68284362tert-butyl 2-(3-carbamoyl-1H-pyrazolo[3,4-c]pyridin-1-yl)acetate

Product 1

HCID 682831141H-Pyrazolo[3,4-c]pyridine-1-acetic acid, 3-(aminocarbonyl)-

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To a solution of tert-butyl 2-(3-carbamoyl-1H-pyrazolo[3,4-c]pyridin-1-yl)acetate (663 mg, 2.40 mmol) in CH2Cl2 (20 mL) was added TFA (10 mL, 130 mmol), and the resulting mixture was stirred at RT for 6 h. The reaction mixture was concentrated in vacuo, the residual solid was suspended in methanol and volatiles were removed again in vacuo to give the title compound.

Workup

  1. concentrationThe reaction mixture was concentrated in vacuo
  2. customvolatiles were removed again in vacuo

Sources & evidence

ORD record
ord-8cb66e40a0344627946f221bcf5fc74e
Source dataset
uspto-grants-2015_07
Patent number
US09085555B2

Reaction notes

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