反应详情

To a solution of (2R,5S)-2-(acetylamino-methyl)-5-(3-trifluoromethoxy-phenylcarbamoyl)-pyrrolidine-1-carboxylic acid benzyl ester (48 mg, 0.1 mmol) in THF (0.3 mL) was added Pd/C (10%, 2.1 mg). The solution was degassed 3 times replacing air by nitrogen and finally nitrogen by hydrogen. The reaction mixture was further stirred under hydrogen atmosphere for 5 h. The catalyst was removed through a pad of Celite and washed with THF. Solvents were concentrated and the resulting residue was used without further purification in the next step. MS (LC/MS): 346 [M+H]+; tR (HPLC conditions b): 2.94 min.

1. customThe solution was degassed 3 times
2. customThe catalyst was removed through a pad of Celite
3. washwashed with THF
4. concentrationSolvents were concentrated
5. customthe resulting residue was used without further purification in the next step
6. custom2.94 min.