Ethyl Acetate → HCID 71009709, compound

HRID 1527369Notes

Reaction equation

HRID 1527369 reaction equation
[C:1]([O:5][C:6]([N:8]1[C@H:13]([C:14](=[O:28])[NH:15][C@@H:16]([C:20]2[CH:25]=[CH:24][CH:23]=[C:22]([Cl:26])[C:21]=2[F:27])[CH2:17][CH2:18][OH:19])[CH2:12][C@@H:11]2[C@H:9]1[CH2:10]2)=[O:7])([CH3:4])([CH3:3])[CH3:2].[CH3:29]COC(C)=O>>[C:1]([O:5][C:6]([N:8]1[C@H:13]([C:14](=[O:28])[NH:15][C@@H:16]([C:20]2[CH:25]=[CH:24][CH:23]=[C:22]([Cl:26])[C:21]=2[F:27])[CH2:17][CH2:18][O:19][CH3:29])[CH2:12][C@@H:11]2[C@H:9]1[CH2:10]2)=[O:7])([CH3:4])([CH3:2])[CH3:3]

Participants

3

Reactant 2

HCID 8857Ethyl AcetateHCID 68284189HCID 68284189, compound

Product 1

HCID 71009709HCID 71009709, compound

Procedure

was prepared according to Scheme B9 (Step B) from (1R,3S,5R)-3-[(R)-1-(3-chloro-2-fluoro-phenyl)-3-hydroxy-propylcarbamoyl]-2-aza-bicyclo[3.1.0]hexane-2-carboxylic acid tert-butyl ester. TLC, Rf (EtOAc)=0.82; MS (UPLC/MS): 427.4/429.4 [M+H]+, 471.4 [M+HCOO]−; tR (HPLC conditions a): 3.71 min.

Workup

  1. customwas prepared
  2. custom3.71 min.

Sources & evidence

ORD record
ord-440cb1c85a4845218613ec2c38b720a4
Source dataset
uspto-grants-2015_07
Patent number
US09085555B2

Reaction notes

Loading…