HCID 68283597, compound → HCID 68284665, compound

HRID 1527371Notes

Reaction equation

HRID 1527371 reaction equation
[C:1]([O:5][C:6]([N:8]1[CH2:12][C@@:11]([F:14])([CH3:13])[CH2:10][C@H:9]1[C:15]([OH:17])=O)=[O:7])([CH3:4])([CH3:3])[CH3:2].[NH2:18][C@@H:19]([C:23]1[CH:28]=[CH:27][CH:26]=[C:25]([Cl:29])[C:24]=1[F:30])[CH2:20][CH2:21][OH:22]>CCOC(C)=O>[C:1]([O:5][C:6]([N:8]1[CH2:12][C@@:11]([F:14])([CH3:13])[CH2:10][C@H:9]1[C:15](=[O:17])[NH:18][C@@H:19]([C:23]1[CH:28]=[CH:27][CH:26]=[C:25]([Cl:29])[C:24]=1[F:30])[CH2:20][CH2:21][OH:22])=[O:7])([CH3:2])([CH3:3])[CH3:4]

Participants

4

Reactant 2

HCID 68283597HCID 68283597, compoundHCID 68283895HCID 68283895, compound

Product 1

HCID 68284665HCID 68284665, compound

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

was prepared according to Scheme B9 (Step A) from (2S,4R)-4-fluoro-4-methyl-pyrrolidine-1,2-dicarboxylic acid 1-tert-butyl ester (prepared as described Scheme B18) and (R)-3-amino-3-(3-chloro-2-fluoro-phenyl)-propan-1-ol. TLC, Rf (EtOAc)=0.55; MS (UPLC/MS): 433.3 [M+H]+, 477.3 [M+HCOO]−; tR (HPLC conditions a): 3.26 min.

Workup

  1. customwas prepared
  2. custom3.26 min.

Sources & evidence

ORD record
ord-050cb90581c5443b892d4d92602f8b89
Source dataset
uspto-grants-2015_07
Patent number
US09085555B2

Reaction notes

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