Trifluoroacetic acid → HCID 68283858, compound

HRID 1527379Notes

Reaction equation

HRID 1527379 reaction equation
C(O)(C(F)(F)F)=O.[Cl:8][C:9]1[C:10]([F:17])=[C:11]([CH:14]=[CH:15][CH:16]=1)[CH2:12][NH2:13].C(OC([N:25]1[CH2:29][C@H:28]([F:30])[CH2:27][C@H:26]1[C:31](O)=[O:32])=O)(C)(C)C>>[Cl:8][C:9]1[C:10]([F:17])=[C:11]([CH:14]=[CH:15][CH:16]=1)[CH2:12][NH:13][C:31]([C@@H:26]1[CH2:27][C@@H:28]([F:30])[CH2:29][NH:25]1)=[O:32]

Participants

4

Reactant 3

HCID 6422Trifluoroacetic acidHCID 2773614(3-Chloro-2-fluorophenyl)methanamineHCID 12043048(2S,4R)-1-[(tert-butoxy)carbonyl]-4-fluoropyrrolidine-2-carboxylic acid

Product 1

HCID 68283858HCID 68283858, compound

Procedure

The title compound was prepared as a TFA salt according to Scheme D5 (steps A and B) from 3-chloro-2-fluoro-benzylamine and (2S,4R)-4-fluoro-pyrrolidine-1,2-dicarboxylic acid 1-tert-butyl ester. MS (LC-MS): 274.9 [M+H]+; tR (HPLC conditions b): 2.23 min.

Workup

  1. custom2.23 min.

Sources & evidence

ORD record
ord-99a8c4b92924410f857523e64494ec1f
Source dataset
uspto-grants-2015_07
Patent number
US09085555B2

Reaction notes

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