HCID 68283857, compound → HCID 68283275, compound

HRID 1527409Notes

Reaction equation

HRID 1527409 reaction equation
[C:1]([O:5][C:6]([N:8]1[CH2:12][C@@H:11]([NH:13][C:14](=[O:16])[CH3:15])[C@H:10]([F:17])[C@H:9]1[C:18]([O:20]CC1C=CC=CC=1)=[O:19])=[O:7])([CH3:4])([CH3:3])[CH3:2]>CO.[Pd]>[C:1]([O:5][C:6]([N:8]1[CH2:12][C@@H:11]([NH:13][C:14](=[O:16])[CH3:15])[C@H:10]([F:17])[C@H:9]1[C:18]([OH:20])=[O:19])=[O:7])([CH3:2])([CH3:3])[CH3:4]

Participants

4

Reactant 1

HCID 68283857HCID 68283857, compound

Product 1

HCID 68283275HCID 68283275, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

A solution of (2R,3S,4R)-4-acetylamino-3-fluoro-pyrrolidine-1,2-dicarboxylic acid 2-benzyl ester 1-tert-butyl ester (315 mg, 0.82 mmol) in methanol (2 mL) was hydrogenated with palladium on carbon 10% (88 mg, 0.82 mmol) overnight. The reaction mixture was filtered over glass fiber and was concentrated. The residue was used as was for the next step.

Workup

  1. filtrationThe reaction mixture was filtered over glass fiber
  2. concentrationwas concentrated

Sources & evidence

ORD record
ord-85599cd9e9cd4a63bf50377af2331de7
Source dataset
uspto-grants-2015_07
Patent number
US09085555B2

Reaction notes

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