Iodine → HCID 68283768, compound

Temperature

-78 °C

To a solution of 1-fluoro-2-(trifluoromethoxy)benzene [2106-18-5] (20.0 g, 111 mmol) in dry THF (200 mL), cooled to −78° C., was added dropwise n-BuLi (2.5 M solution in n-hexane; 65 mL, 160 mmol) and subsequently TMEDA (60 mL). The reaction mixture was stirred for additional 60 min at −78° C., followed by addition of a solution of iodine (30.2 g, 120 mmol) in dry THF (50 mL). The resulting mixture was stirred for 1 h and then quenched by addition of a saturated aqueous NH4Cl solution (20 mL). The organic layer was washed with 1N HCl, water and brine, and dried over MgSO4. Volatiles were removed in vacuo to afford the title compound as yellow oil. The product was used in the next reaction step without further purification. MS (LC/MS): 306.0 [M+H]+.

1. stirringThe resulting mixture was stirred for 1 h
2. customquenched by addition of a saturated aqueous NH4Cl solution (20 mL)
3. washThe organic layer was washed with 1N HCl, water and brine
4. dry with materialdried over MgSO4
5. customVolatiles were removed in vacuo

ORD record

ord-e87bba9db86347c29192296e23d8e613

Source dataset

uspto-grants-2015_07

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US09085555B2