Trifluoroacetic acid → (3-Aminomethyl-5-chloro-4-fluoro-phenyl)-diethyl-amine

HRID 1527479Notes

Reaction equation

HRID 1527479 reaction equation
C(OC(=O)[NH:7][CH2:8][C:9]1[CH:14]=[C:13]([N:15]([CH2:18][CH3:19])[CH2:16][CH3:17])[CH:12]=[C:11]([Cl:20])[C:10]=1[F:21])(C)(C)C.C(O)(C(F)(F)F)=O>C(Cl)Cl>[NH2:7][CH2:8][C:9]1[CH:14]=[C:13]([N:15]([CH2:18][CH3:19])[CH2:16][CH3:17])[CH:12]=[C:11]([Cl:20])[C:10]=1[F:21]

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 68283679(3-Chloro-5-diethylamino-2-fluoro-benzyl)-carbamic acid tert-butyl ester

Product 1

HCID 71009409(3-Aminomethyl-5-chloro-4-fluoro-phenyl)-diethyl-amine

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

was prepared according to Scheme C1 (step B) from (3-chloro-5-diethylamino-2-fluoro-benzyl)-carbamic acid tert-butyl ester and TFA in CH2Cl2. MS (LC-MS): 231.0 [M]+; tR (HPLC conditions c): 2.29 min.

Workup

  1. customwas prepared
  2. custom2.29 min.

Sources & evidence

ORD record
ord-4aec3db98f8a4bc98b3ea59a082503b2
Source dataset
uspto-grants-2015_07
Patent number
US09085555B2

Reaction notes

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