Hydrochloric Acid → HCID 71009400, compound

HRID 1527483Notes

Reaction equation

HRID 1527483 reaction equation
C(OC(=O)[NH:7][CH2:8][C:9]1[CH:14]=[C:13]([N:15]2[CH2:20][CH2:19]N(C)[CH2:17][CH2:16]2)[CH:12]=[C:11]([Cl:22])[C:10]=1[F:23])(C)(C)C.Cl.[O:26]1[CH2:31]COC[CH2:27]1>>[Cl:22][C:11]1[C:10]([F:23])=[C:9]([CH:14]=[C:13]([N:15]2[CH2:16][CH2:17][CH:27]([O:26][CH3:31])[CH2:19][CH2:20]2)[CH:12]=1)[CH2:8][NH2:7]

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 312751,4-DioxaneHCID 68284192[3-Chloro-2-fluoro-5-(4-methyl-piperazin-1-yl)-benzyl]-carbamic acid tert-butyl ester

Product 1

HCID 71009400HCID 71009400, compound

Procedure

was prepared according to Scheme C1 (step B) from [3-chloro-2-fluoro-5-(4-methyl-piperazin-1-yl)-benzyl]-carbamic acid tert-butyl ester and 4N HCl in dioxane. MS (LC-MS): 273.0 [M]+; tR (HPLC conditions c): 2.97 min.

Workup

  1. customwas prepared
  2. custom2.97 min.

Sources & evidence

ORD record
ord-687ca058b61a404ba6a0f644c5f36c87
Source dataset
uspto-grants-2015_07
Patent number
US09085555B2

Reaction notes

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