Hydrochloric Acid → HCID 68283516, compound

HRID 1527493Notes

Reaction equation

HRID 1527493 reaction equation
C(OC(=O)[NH:7][CH2:8][C:9]1[CH:14]=[C:13]([CH2:15][N:16]2[CH2:21][CH2:20][N:19]([CH3:22])[CH2:18][CH2:17]2)[CH:12]=[C:11]([Cl:23])[C:10]=1[F:24])(C)(C)C.Cl>O1CCOCC1>[Cl:23][C:11]1[C:10]([F:24])=[C:9]([CH:14]=[C:13]([CH2:15][N:16]2[CH2:21][CH2:20][N:19]([CH3:22])[CH2:18][CH2:17]2)[CH:12]=1)[CH2:8][NH2:7]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 68284159[3-Chloro-2-fluoro-5-(4-methyl-piperazin-1-ylmethyl)-benzyl]-carbamic acid tert-butyl ester

Product 1

HCID 68283516HCID 68283516, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

was prepared according to Scheme C2 (step D) from [3-chloro-2-fluoro-5-(4-methyl-piperazin-1-ylmethyl)-benzyl]-carbamic acid tert-butyl ester (225 mg, 0.61 mmol) and 4N HCl in dioxane. MS (LC-MS): 272.0 [M]+; tR (HPLC conditions c): 2.07 min.

Workup

  1. customwas prepared
  2. custom2.07 min.

Sources & evidence

ORD record
ord-659d1a6bd7a2415a94d504d3c2a5044b
Source dataset
uspto-grants-2015_07
Patent number
US09085555B2

Reaction notes

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