Hydrochloric Acid → N-(3-Aminomethyl-5-chloro-4-fluoro-benzyl)-N,N',N'-trimethyl-ethane-1,2-diamine

HRID 1527499Notes

Reaction equation

HRID 1527499 reaction equation
C(OC(=O)[NH:7][CH2:8][C:9]1[CH:14]=[C:13]([CH2:15][N:16]([CH2:18][CH2:19][N:20]([CH3:22])[CH3:21])[CH3:17])[CH:12]=[C:11]([Cl:23])[C:10]=1[F:24])(C)(C)C.Cl>O1CCOCC1>[NH2:7][CH2:8][C:9]1[CH:14]=[C:13]([CH:12]=[C:11]([Cl:23])[C:10]=1[F:24])[CH2:15][N:16]([CH3:17])[CH2:18][CH2:19][N:20]([CH3:22])[CH3:21]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 68284327(3-Chloro-5-{[(2-dimethylamino-ethyl)-methyl-amino]-methyl}-2-fluoro-benzyl)-carbamic acid tert-butyl ester

Product 1

HCID 71009469N-(3-Aminomethyl-5-chloro-4-fluoro-benzyl)-N,N',N'-trimethyl-ethane-1,2-diamine

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

was prepared according to Scheme C2 (step D) from (3-chloro-5-{[(2-dimethylamino-ethyl)-methyl-amino]-methyl}-2-fluoro-benzyl)-carbamic acid tert-butyl ester (228 mg, 0.51 mmol) and 4N HCl in dioxane. MS (LC-MS): 274.0 [M]+.

Workup

  1. customwas prepared

Sources & evidence

ORD record
ord-c8b2878bc0314b40bd2a01b2d3d50eee
Source dataset
uspto-grants-2015_07
Patent number
US09085555B2

Reaction notes

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