Trifluoroacetic acid → (3-Aminomethyl-5-chloro-4-fluoro-phenyl)-(3-methoxy-azetidin-1-yl)-methanone

HRID 1527506Notes

Reaction equation

HRID 1527506 reaction equation
C(OC(=O)[NH:7][CH2:8][C:9]1[CH:14]=[C:13]([C:15]([N:17]2[CH2:20][CH:19]([O:21][CH3:22])[CH2:18]2)=[O:16])[CH:12]=[C:11]([Cl:23])[C:10]=1[F:24])(C)(C)C.C(O)(C(F)(F)F)=O>C(Cl)Cl>[NH2:7][CH2:8][C:9]1[CH:14]=[C:13]([C:15]([N:17]2[CH2:18][CH:19]([O:21][CH3:22])[CH2:20]2)=[O:16])[CH:12]=[C:11]([Cl:23])[C:10]=1[F:24]

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 68283498[3-Chloro-2-fluoro-5-(3-methoxy-azetidine-1-carbonyl)-benzyl]-carbamic acid tert-butyl ester

Product 1

HCID 68284286(3-Aminomethyl-5-chloro-4-fluoro-phenyl)-(3-methoxy-azetidin-1-yl)-methanone

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

was prepared according to Scheme C3 (step B) from [3-chloro-2-fluoro-5-(3-methoxy-azetidine-1-carbonyl)-benzyl]-carbamic acid tert-butyl ester (99 mg, 0.3 mmol) and TFA (0.5 mL) in CH2Cl2. MS (LC-MS): 273.0 [M]+; tR (HPLC conditions c): 2.73 min.

Workup

  1. customwas prepared
  2. custom2.73 min.

Sources & evidence

ORD record
ord-269d501394f34848a6e689f622210b8a
Source dataset
uspto-grants-2015_07
Patent number
US09085555B2

Reaction notes

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