HuagongsheHuagongshe Chemistry Print Report · For research reference only
Trifluoroacetic acid → 3-Aminomethyl-5-chloro-N-(2-dimethylamino-ethyl)-4-fluoro-benzamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Trifluoroacetic acid | HCID 6422 | — |
| Reactant | [3-Chloro-5-(2-dimethylamino-ethylcarbamoyl)-2-fluoro-benzyl]-carbamic acid tert-butyl ester | HCID 68283713 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 3-Aminomethyl-5-chloro-N-(2-dimethylamino-ethyl)-4-fluoro-benzamide | HCID 68283043 | — |
Reaction Steps
was prepared according to Scheme C3 (step B) from [3-chloro-5-(2-dimethylamino-ethylcarbamoyl)-2-fluoro-benzyl]-carbamic acid tert-butyl ester (120 mg, 0.3 mmol) and TFA (1 mL) in CH2Cl2. MS (LC-MS): 274.0 [M]+; tR (HPLC conditions c): 2.17 min.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09085555B2 |
| Source dataset | uspto-grants-2015_07 |
| ORD ID | ord-2344b629bcd9444da031ef7a39d29d76 |
| Source note | uspto-grants-2015_07 |