Trifluoroacetic acid → 3-Aminomethyl-5-chloro-N-(2-dimethylamino-ethyl)-4-fluoro-benzamide

HRID 1527508Notes

Reaction equation

HRID 1527508 reaction equation
C(OC(=O)[NH:7][CH2:8][C:9]1[CH:14]=[C:13]([C:15](=[O:22])[NH:16][CH2:17][CH2:18][N:19]([CH3:21])[CH3:20])[CH:12]=[C:11]([Cl:23])[C:10]=1[F:24])(C)(C)C.C(O)(C(F)(F)F)=O>C(Cl)Cl>[NH2:7][CH2:8][C:9]1[CH:14]=[C:13]([CH:12]=[C:11]([Cl:23])[C:10]=1[F:24])[C:15]([NH:16][CH2:17][CH2:18][N:19]([CH3:21])[CH3:20])=[O:22]

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 68283713[3-Chloro-5-(2-dimethylamino-ethylcarbamoyl)-2-fluoro-benzyl]-carbamic acid tert-butyl ester

Product 1

HCID 682830433-Aminomethyl-5-chloro-N-(2-dimethylamino-ethyl)-4-fluoro-benzamide

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

was prepared according to Scheme C3 (step B) from [3-chloro-5-(2-dimethylamino-ethylcarbamoyl)-2-fluoro-benzyl]-carbamic acid tert-butyl ester (120 mg, 0.3 mmol) and TFA (1 mL) in CH2Cl2. MS (LC-MS): 274.0 [M]+; tR (HPLC conditions c): 2.17 min.

Workup

  1. customwas prepared
  2. custom2.17 min.

Sources & evidence

ORD record
ord-2344b629bcd9444da031ef7a39d29d76
Source dataset
uspto-grants-2015_07
Patent number
US09085555B2

Reaction notes

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