Trifluoroacetic acid → (3-Aminomethyl-5-chloro-4-fluoro-phenyl)-morpholin-4-yl-methanone

HRID 1527510Notes

Reaction equation

HRID 1527510 reaction equation
C(OC(=O)[NH:7][CH2:8][C:9]1[CH:14]=[C:13]([C:15]([N:17]2[CH2:22][CH2:21][O:20][CH2:19][CH2:18]2)=[O:16])[CH:12]=[C:11]([Cl:23])[C:10]=1[F:24])(C)(C)C.C(O)(C(F)(F)F)=O>C(Cl)Cl>[NH2:7][CH2:8][C:9]1[CH:14]=[C:13]([C:15]([N:17]2[CH2:22][CH2:21][O:20][CH2:19][CH2:18]2)=[O:16])[CH:12]=[C:11]([Cl:23])[C:10]=1[F:24]

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 68283707[3-Chloro-2-fluoro-5-(morpholine-4-carbonyl)-benzyl]-carbamic acid tert-butyl ester

Product 1

HCID 68283657(3-Aminomethyl-5-chloro-4-fluoro-phenyl)-morpholin-4-yl-methanone

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

was prepared according to Scheme C3 (step B) from [3-chloro-2-fluoro-5-(morpholine-4-carbonyl)-benzyl]-carbamic acid tert-butyl ester (72 mg, 0.19 mmol) and TFA (1 mL) in CH2Cl2. MS (LC-MS): 273.0 [M]+; tR (HPLC conditions c): 2.64 min.

Workup

  1. customwas prepared
  2. custom2.64 min.

Sources & evidence

ORD record
ord-5b9695d8875a4ecb9022e712ae575014
Source dataset
uspto-grants-2015_07
Patent number
US09085555B2

Reaction notes

Loading…