Hydrochloric Acid → HCID 71009696, compound

HRID 1527523Notes

Reaction equation

HRID 1527523 reaction equation
[Cl:1][C:2]1[C:3]([F:19])=[C:4]([C:8]2([NH:12]S(C(C)(C)C)=O)[CH2:11][O:10][CH2:9]2)[CH:5]=[CH:6][CH:7]=1.Cl>CO>[ClH:1].[Cl:1][C:2]1[C:3]([F:19])=[C:4]([C:8]2([NH2:12])[CH2:9][O:10][CH2:11]2)[CH:5]=[CH:6][CH:7]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 86673868HCID 86673868, compound

Product 1

HCID 71009696HCID 71009696, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

A solution of 2-methyl-propane-2-sulfinic acid [3-(3-chloro-2-fluoro-phenyl)-oxetan-3-yl]-amide (940 mg, 2.46 mmol) and hydrochloric acid (4 N in dioxane, 0.922 ml, 3.69 mmol) in MeOH (5 mL) was stirred 30 min at 0° C. and concentrated. The material thus obtained was used without further purification in the next step. MS (UPLC-MS): 202/204 [M+H]+; tR (HPLC conditions f): 0.86 min.

Workup

  1. concentrationconcentrated
  2. customThe material thus obtained
  3. customwas used without further purification in the next step
  4. custom0.86 min.

Sources & evidence

ORD record
ord-42a4be781c3c48cb9e64157f19ec46a4
Source dataset
uspto-grants-2015_07
Patent number
US09085555B2

Reaction notes

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