Trifluoroacetic acid → Trifluoroacetic acid

Participants

Reaction Steps

A solution of (S)-2-[(3-trifluoromethoxy-phenylamino)-methyl]-pyrrolidine-1-carboxylic acid tert-butyl ester (100 mg, 0.277 mmol) and TFA (1 mLl) in CH2Cl2 (2 mL) was stirred at RT for 2 h. Solvent was concentrated and the residue was co-evaporated twice with CH2Cl2 and dried under high vacuum overnight to give the crude title compound as a TFA salt. MS: 261.1 [MH−Boc]+, tR (HPLC conditions a): 2.61 min.

Provenance & Evidence