Trifluoroacetic acid → Trifluoroacetic acid

HRID 1527539Notes

Reaction equation

HRID 1527539 reaction equation
C(OC([N:8]1[CH2:12][CH2:11][CH2:10][C@H:9]1[CH2:13][NH:14][C:15]1[CH:20]=[CH:19][CH:18]=[C:17]([O:21][C:22]([F:25])([F:24])[F:23])[CH:16]=1)=O)(C)(C)C.[C:26]([OH:32])([C:28]([F:31])([F:30])[F:29])=[O:27]>C(Cl)Cl>[NH:8]1[CH2:12][CH2:11][CH2:10][C@H:9]1[CH2:13][NH:14][C:15]1[CH:20]=[CH:19][CH:18]=[C:17]([O:21][C:22]([F:23])([F:24])[F:25])[CH:16]=1.[C:26]([OH:32])([C:28]([F:31])([F:30])[F:29])=[O:27]

Participants

5

Reactant 2

HCID 6422Trifluoroacetic acidHCID 68283518HCID 68283518, compound

Product 2

HCID 6422Trifluoroacetic acidHCID 68284180HCID 68284180, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

A solution of (S)-2-[(3-trifluoromethoxy-phenylamino)-methyl]-pyrrolidine-1-carboxylic acid tert-butyl ester (100 mg, 0.277 mmol) and TFA (1 mLl) in CH2Cl2 (2 mL) was stirred at RT for 2 h. Solvent was concentrated and the residue was co-evaporated twice with CH2Cl2 and dried under high vacuum overnight to give the crude title compound as a TFA salt. MS: 261.1 [MH−Boc]+, tR (HPLC conditions a): 2.61 min.

Workup

  1. concentrationSolvent was concentrated
  2. customdried under high vacuum overnight

Sources & evidence

ORD record
ord-d42bab69efaa41999227b245788788c3
Source dataset
uspto-grants-2015_07
Patent number
US09085555B2

Reaction notes

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