Sodium Hydroxide → HCID 68284212, compound

HRID 1527578Notes

Reaction equation

HRID 1527578 reaction equation
C[O:2][C:3](=[O:45])[C:4]1[CH:9]=[CH:8][C:7]([CH:10]([O:32][C:33]2[CH:41]=[C:40]3[C:36]([C:37]([C:42](=[O:44])[CH3:43])=[CH:38][NH:39]3)=[CH:35][CH:34]=2)[CH2:11][C:12]([N:14]2[CH2:18][C@H:17]([F:19])[CH2:16][C@H:15]2[C:20](=[O:31])[NH:21][CH2:22][C:23]2[CH:28]=[CH:27][CH:26]=[C:25]([Cl:29])[C:24]=2[F:30])=[O:13])=[CH:6][CH:5]=1.[OH-].[Na+]>C1COCC1.O>[C:42]([C:37]1[C:36]2[C:40](=[CH:41][C:33]([O:32][CH:10]([C:7]3[CH:6]=[CH:5][C:4]([C:3]([OH:45])=[O:2])=[CH:9][CH:8]=3)[CH2:11][C:12]([N:14]3[CH2:18][C@H:17]([F:19])[CH2:16][C@H:15]3[C:20](=[O:31])[NH:21][CH2:22][C:23]3[CH:28]=[CH:27][CH:26]=[C:25]([Cl:29])[C:24]=3[F:30])=[O:13])=[CH:34][CH:35]=2)[NH:39][CH:38]=1)(=[O:44])[CH3:43]

Participants

5

Reactant 2

HCID 14798Sodium HydroxideHCID 68284166HCID 68284166, compound

Product 1

HCID 68284212HCID 68284212, compound

Reagents, catalysts & solvents 2

HCID 962WaterSolventHCID 8028TetrahydrofuranSolvent

Procedure

The title compound was prepared in a similar manner as described for Example 595 from 4-(3-acetyl-1-{2-[(2S,4R)-2-(3-chloro-2-fluoro-benzylcarbamoyl)-4-fluoro-pyrrolidin-1-yl]-2-oxo-ethyl}-1H-indol-6-yloxymethyl)-benzoic acid methyl ester (37.0 mg, 0.058 mmol) and 1N NaOH (0.928 mL, 0.928 mmol) in THF (5 mL) and water (0.5 mL). Solid. MS (LC/MS): 624/626 [M+H]+; tR (HPLC conditions k): 3.48 min.

Workup

  1. custom3.48 min.

Sources & evidence

ORD record
ord-fbbc4ec27af9473eac0a995495d4ea1b
Source dataset
uspto-grants-2015_07
Patent number
US09085555B2

Reaction notes

Loading…