huagongshe.com
HRID1527584

反应详情

EQUATION

反应方程式

HRID 1527584 的结构方程式

REACTANTS

反应物

3
结构：CC(=O)c1cn(CC(=O)O)c2ccccc12
HCID1088616

(3-Acetyl-indol-1-yl)-acetic acid

C12H11NO3

结构：CC(C)(C)OC(=O)N1C[C@@H]2C[C@@H]2[C@H]1C(=O)N[C@H](CO)c1cccc(Cl)c1F
HCID68283613

未命名化合物

结构：CC(=O)c1cn(CC(=O)N2[C@H](C(=O)NCc3cccc(Cl)c3F)C[C@@]3(CO)C[C@@H]23)c2ncccc12
HCID68283700

未命名化合物

PRODUCTS

生成物

1
结构：CC(=O)c1cn(CC(=O)N2C[C@@H]3C[C@@H]3[C@H]2C(=O)N[C@H](CO)c2cccc(Cl)c2F)c2ccccc12
HCID71042476

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

1
结构：CCOC(C)=O
溶剂HCID8857

Ethyl acetate

C4H8O2

PROCEDURE

实验过程

The title compound was prepared in 2 steps according to the procedure described for the preparation of Example 610 (1R,3S,5S)-2-[2-(3-acetyl-pyrrolo[2,3-b]pyridin-1-yl)-acetyl]-5-hydroxymethyl-2-aza-bicyclo[3.1.0]hexane-3-carboxylic acid 3-chloro-2-fluoro-benzylamide from (1S,2S,5R)-2-[(S)-1-(3-chloro-2-fluoro-phenyl)-2-hydroxy-ethylcarbamoyl]-3-aza-bicyclo[3.1.0]hexane-3-carboxylic acid tert-butyl ester (prepared using similar protocols as described in Scheme B9) and (3-acetyl-indol-1-yl)-acetic acid. White powder. TLC, Rf (EtOAc)=0.10; MS (UPLC/MS): 498.3/500.4 [M+H]+, 542.4/544.3 [M+HCOO]−; tR (HPLC conditions a): 3.10 min.

WORKUP

后处理

  1. custom3.10 min.