反应详情

To a suspension of 4.38 g of 2-(1-imidazolylcarbonylamino)-6-methyl-4[1H]-pyrimidinone 1A (0.02 mol) in 200 ml of ethyl acetate were added 7.4 g of 2,5,8,11,14,17,20 heptaoxadocosan-22-amine (0.0218 mol). The reaction mixture was refluxed for 12 hours. The mixture was then allowed to return to room temperature, and was evaporated under reduced pressure. The residue was taken up in acetone (50 ml) and then filtered to remove the imidazole. The filtrate was evaporated under reduced pressure and then taken up again in 50 ml of acetone and filtered. The filtrate was evaporated under reduced pressure. 5.9 g of the expected product were thus obtained in the form of a pasty oil, in a yield of 60%. 1H and 13C NMR spectra compliant.

1. temperatureThe reaction mixture was refluxed for 12 hours
2. customto return to room temperature
3. customwas evaporated under reduced pressure
4. filtrationfiltered
5. customto remove the imidazole
6. customThe filtrate was evaporated under reduced pressure
7. filtrationfiltered
8. customThe filtrate was evaporated under reduced pressure