反应详情

温度

50 °C

A mixture of 5-ethyl-4-(furan-2-yl)-pyrimidine (2.03 g), acetone (70 ml), and water (35 ml) was stirred at 50° C., potassium permanganate (15 g) was added thereto over 15 minutes, and the reaction mixture was stirred under reflux for 1 hour. After standing to cool the reaction mixture to room temperature, to the reaction mixture, saturated aqueous sodium hydrogen carbonate solution was added, and extracted with tert-butyl methyl ether. To the resulting aqueous layer, hydrochloric acid was added, and extracted with tert-butyl methyl ether. The organic layer was dried over sodium sulfate, and concentrated under reduced pressure to give 1.14 g of 5-ethyl-pyrimidine-4-carboxylic acid.

1. stirringthe reaction mixture was stirred
2. temperatureunder reflux for 1 hour
3. temperatureto cool the reaction mixture to room temperature
4. extractionextracted with tert-butyl methyl ether
5. additionTo the resulting aqueous layer, hydrochloric acid was added
6. extractionextracted with tert-butyl methyl ether
7. dry with materialThe organic layer was dried over sodium sulfate
8. concentrationconcentrated under reduced pressure