HuagongsheHuagongshe Chemistry Print Report · For research reference only
(E)-3-(3-Bromo-1,4-naphthoquinon-2-yl)-2-methylpropenoic Acid → 3-(3-Chloro-1,4-dihydronaphthalen-2-yl)-2-methylacrylic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (E)-3-(3-Bromo-1,4-naphthoquinon-2-yl)-2-methylpropenoic Acid | HCID 25235467 | — |
| Reactant | (E)-3-(3-chloro-1,4-dimethoxynaphthalen-2-yl)-2-methylpropenoic acid | HCID 46180319 | — |
| Solvent | Acetone | HCID 180 | — |
| Product | 3-(3-Chloro-1,4-dihydronaphthalen-2-yl)-2-methylacrylic acid | HCID 25235426 | — |
Reaction Steps
Compound 43a was prepared from 42a (0.872 g, 2.84 mmol) as described above for 39a to give 0.121 g (0.437 mmol, 16%) of the product as a yellow solid following flash chromatography (2:3 acetone:hexanes 0.5% AcOH) and recrystallization from Et2O/hexanes. (0.121 g E; 0.115 g Z methyl ester)
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09089605B2 |
| Source dataset | uspto-grants-2015_07 |
| ORD ID | ord-7d4815dec19844c08c0afe7b8f56bc9c |
| Source note | uspto-grants-2015_07 |