HuagongsheHuagongshe Chemistry Print Report · For research reference only
(E)-3-(3-Bromo-1,4-naphthoquinon-2-yl)-2-methylpropenoic Acid → (E)-3-(3-Fluoro-1,4-naphthoquinon-2-yl)-2-methylpropenoic Acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (E)-3-(3-Bromo-1,4-naphthoquinon-2-yl)-2-methylpropenoic Acid | HCID 25235467 | — |
| Reactant | (E)-3-(1,4-dimethoxy-3-fluoronaphthalen-2-yl)-2-methylpropenoic acid | HCID 46180317 | — |
| Solvent | Acetone | HCID 180 | — |
| Product | (E)-3-(3-Fluoro-1,4-naphthoquinon-2-yl)-2-methylpropenoic Acid | HCID 25235425 | — |
Reaction Steps
Compound 52 was prepared from 99d (0.097 g, 0.33 mmol) as described above for 39a to give 0.020 g (0.08 mmol, 23%) of the product as a yellow solid following flash chromatography (3:17 acetone:hexanes 0.5% AcOH) and recrystallization from Et2O/hexanes. (0.020 g E; 0.015 g E starting material; 0.023 g Z methyl ester)
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09089605B2 |
| Source dataset | uspto-grants-2015_07 |
| ORD ID | ord-50d1770c510a45459c00b5b84e660936 |
| Source note | uspto-grants-2015_07 |