反应详情

温度

140 °C

A mixture of 5-methoxy-2-nitroaniline (513 mg, 3 mmol), 4-bromo-2,6-difluorobenzyl amine (616 g, 3 mmol), DIPEA (1.55 mL, 9 mmol) and acetonitrile (10 mL) was heated to 130-150° Celsius for 16 h. The mixture was then cooled to RT and concentrated to dryness. To the residue was added H2O (100 mL) and the resulting solid was collected by filtration and dried to afford the title compound (900 mg, 80.1%).

1. temperatureThe mixture was then cooled to RT
2. concentrationconcentrated to dryness
3. additionTo the residue was added H2O (100 mL)
4. filtrationthe resulting solid was collected by filtration
5. customdried