Hydrochloric Acid → HCID 86762293, compound

HRID 1527843Notes

Reaction equation

HRID 1527843 reaction equation
[C:1]([O:9][CH2:10][CH2:11][N:12]([CH2:21][C:22]([O:24]C(C)(C)C)=[O:23])[CH2:13][C:14](=[O:20])[O:15]C(C)(C)C)(=[O:8])/[CH:2]=[CH:3]/[C:4]([O:6][CH3:7])=[O:5].[ClH:29]>O1CCOCC1>[ClH:29].[CH3:7][O:6][C:4](=[O:5])/[CH:3]=[CH:2]/[C:1]([O:9][CH2:10][CH2:11][N:12]([CH2:13][C:14]([OH:20])=[O:15])[CH2:21][C:22]([OH:24])=[O:23])=[O:8]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 86762295HCID 86762295, compound

Product 1

HCID 86762293HCID 86762293, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent2×

Procedure

To a solution of 2-(bis(2-(tert-butoxy)-2-oxoethyl)amino)ethyl methyl fumarate (2.52 g, 6.2 mmol) in dioxane (25 ml) was added 2M HCl in dioxane (30 ml) and the mixture stirred for 90 hours. The precipitate was filtered, washed with diethyl ether and dried in a vacuum oven at 55° C. for 18 hours to give (E)-2,2′-((2-((4-methoxy-4-oxobut-2-enoyl)oxy)ethyl)azanediyl)diacetic acid hydrochloride, a white solid (1.31 g, 65%).

Workup

  1. filtrationThe precipitate was filtered
  2. washwashed with diethyl ether
  3. customdried in a vacuum oven at 55° C. for 18 hours

Sources & evidence

ORD record
ord-dfc0bd138b73479c8824829e8a832319
Source dataset
uspto-grants-2015_07
Patent number
US09090558B2

Reaction notes

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