Trimethylsilylacetylene → HCID 178437114, compound

HRID 1527858Notes

Reaction equation

HRID 1527858 reaction equation
Br[C:2]1[C:3]2[NH:10][CH:9]=[N:8][C:4]=2[CH:5]=[N:6][CH:7]=1.[C:11]([Si](C)(C)C)#[CH:12]>>[C:11]([C:2]1[C:3]2[NH:10][CH:9]=[N:8][C:4]=2[CH:5]=[N:6][CH:7]=1)#[CH:12]

Participants

3

Reactant 2

HCID 66111TrimethylsilylacetyleneHCID 178419455HCID 178419455, compound

Product 1

HCID 178437114HCID 178437114, compound

Procedure

The title compound can be synthesized from 7-ethynyl-1H-imidazo[4,5-c]pyridine and 3-iodo-4-methyl-N-(4-((4-methylpiperazin-1-yl)methyl)-3-(trifluoromethyl)phenyl)benzamide in a manner similar to that described for Example 1. 7-ethynyl-1H-imidazo[4,5-c]pyridine is prepared from 7-bromo-1H-imidazo[4,5-c]pyridine and ethynyltrimethylsilane according to the 2 steps procedure described in Example 1.

Sources & evidence

ORD record
ord-abad6d0850b941e48eaa8ec24898bb22
Source dataset
uspto-grants-2015_07
Patent number
US09090561B2

Reaction notes

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