Menadione → HCID 67057846, compound

HRID 1528020Notes

Reaction equation

HRID 1528020 reaction equation
[CH3:1][C:2]1[C:12](=[O:13])[C:11]2[CH:10]=[CH:9][CH:8]=[CH:7][C:6]=2[C:4](=[O:5])[CH:3]=1.[CH3:14][O:15][C:16]1[CH:21]=[CH:20][C:19]([O:22][CH3:23])=[CH:18][C:17]=1[CH2:24]C(O)=O>>[CH3:14][O:15][C:16]1[CH:21]=[CH:20][C:19]([O:22][CH3:23])=[CH:18][C:17]=1[CH2:24][C:3]1[C:4](=[O:5])[CH:6]2[CH:11]([C:12](=[O:13])[C:2]=1[CH3:1])[CH:10]=[CH:9][CH:8]=[CH:7]2

Participants

3

Reactant 2

HCID 4055MenadioneHCID 744692,5-Dimethoxyphenylacetic acid

Product 1

HCID 67057846HCID 67057846, compoundYield 80%

Procedure

As starting materials for the coupling reaction menadione and 2,5-dimethoxyphenylacetic acid were used. Synthesis is realized according to the general procedure described in general procedure of example 1. After chromatography on silica gel (petroleum ether:CH2Cl2=1:3, UV), 1.96 g (6.08 mmol, 80% yield) of P_TM60 were isolated as yellow solid.

Workup

  1. customSynthesis

Sources & evidence

ORD record
ord-70a1e0591a42464d88f0383b2214af2d
Source dataset
uspto-grants-2015_07
Patent number
US09090549B2

Reaction notes

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