Menadione → HCID 67057796, compound

HRID 1528023Notes

Reaction equation

HRID 1528023 reaction equation
C[C:2]1[C:12](=[O:13])[C:11]2[CH:10]=[CH:9][CH:8]=[CH:7][C:6]=2[C:4](=[O:5])[CH:3]=1.[CH:14]([C:17]1[CH:22]=[CH:21][C:20]([CH2:23][C:24](O)=O)=[CH:19][CH:18]=1)([CH3:16])[CH3:15]>>[CH3:2][C:3]1[C:4](=[O:5])[CH:6]2[CH:11]([C:12](=[O:13])[C:24]=1[CH2:23][C:20]1[CH:19]=[CH:18][C:17]([CH:14]([CH3:15])[CH3:16])=[CH:22][CH:21]=1)[CH:10]=[CH:9][CH:8]=[CH:7]2

Participants

3

Reactant 2

HCID 4055MenadioneHCID 782304-Isopropylphenylacetic acid

Product 1

HCID 67057796HCID 67057796, compoundYield 58%

Procedure

As starting materials for the coupling reaction menadione and 4-isopropylphenylacetic acid were used. Synthesis is realized according to the general procedure described in general procedure of example 1. After chromatography on silica gel (petroleum ether:CH2Cl2=1:1, UV), 395 mg (1.30 mmol, 58% yield) of P_TM100 were isolated as yellow solid.

Workup

  1. customSynthesis

Sources & evidence

ORD record
ord-b42bbdeaf1c743a5a67897f2401705f0
Source dataset
uspto-grants-2015_07
Patent number
US09090549B2

Reaction notes

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