Menadione → HCID 67057787, compound

HRID 1528024Notes

Reaction equation

HRID 1528024 reaction equation
[CH3:1][C:2]1[C:12](=[O:13])[C:11]2[CH:10]=[CH:9][CH:8]=[CH:7][C:6]=2[C:4](=[O:5])[CH:3]=1.[Br:14][C:15]1[CH:20]=[C:19]([O:21][CH3:22])[CH:18]=[CH:17][C:16]=1[CH2:23]C(O)=O>>[Br:14][C:15]1[CH:20]=[C:19]([O:21][CH3:22])[CH:18]=[CH:17][C:16]=1[CH2:23][C:3]1[C:4](=[O:5])[C:6]2[C:11]([C:12](=[O:13])[C:2]=1[CH3:1])=[CH:10][CH:9]=[CH:8][CH:7]=2

Participants

3

Reactant 2

HCID 4055MenadioneHCID 39636682-Bromo-4-methoxyphenylacetic acid

Product 1

HCID 67057787HCID 67057787, compoundYield 57%

Procedure

As starting materials for the coupling reaction menadione and 2-Bromo-4-methoxyphenylacetic acid were used. Synthesis is realized according to the general procedure described in general procedure of example 1. After chromatography on silica gel (petroleum ether:CH2Cl2=1:1, UV), 857 mg (2.31 mmol, 57% yield) of P_TM102 were isolated as yellow oil.

Workup

  1. customSynthesis

Sources & evidence

ORD record
ord-c3cb222614f94c5abf59bb1144230a8d
Source dataset
uspto-grants-2015_07
Patent number
US09090549B2

Reaction notes

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