Stannous Chloride → (3-(Trifluoromethoxy)phenyl)hydrazine hydrochloride

Temperature

-5 °C

3-(Trifluoromethoxy)aniline (3.68 ml) was dissolved in 6 M hydrochloric acid (71 ml), and an aqueous solution (4.7 ml) of sodium nitrite (2.08 g) was added dropwise over 20 min at −5° C. Tin (II) chloride (1.954 ml) was dissolved in 6 M hydrochloric acid (25 ml), and the solution was cooled to −5° C., and added quickly to the above-mentioned reaction mixture at −5° C. The mixture was stirred at −5° C. for 2 hr, and the precipitated solid was collected by filtration, washed with 0.1M hydrochloric acid, and dried under reduced pressure to give the title compound (2.72 g).

1. additionadded quickly to the above-mentioned reaction mixture at −5° C
2. filtrationthe precipitated solid was collected by filtration
3. washwashed with 0.1M hydrochloric acid
4. customdried under reduced pressure

ORD record

ord-e83942c2d9274a6ea90ca4b06de6ee16

Source dataset

uspto-grants-2015_07

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US09090586B2