Dimethylformamide dimethyl acetal → HCID 71272086, compound

HRID 1528050Notes

Reaction equation

HRID 1528050 reaction equation
[C:1]([C:4]1[C:9](=[O:10])[C:8]([O:11][CH3:12])=[CH:7][N:6]([C:13]2[CH:18]=[CH:17][C:16]([N:19]3[CH:23]=[CH:22][CH:21]=[N:20]3)=[CH:15][C:14]=2[O:24][CH3:25])[N:5]=1)(=[O:3])[CH3:2].CO[CH:28](OC)[N:29]([CH3:31])[CH3:30]>C(#N)C>[CH3:28][N:29]([CH3:31])[CH:30]=[CH:2][C:1]([C:4]1[C:9](=[O:10])[C:8]([O:11][CH3:12])=[CH:7][N:6]([C:13]2[CH:18]=[CH:17][C:16]([N:19]3[CH:23]=[CH:22][CH:21]=[N:20]3)=[CH:15][C:14]=2[O:24][CH3:25])[N:5]=1)=[O:3]

Participants

4

Reactant 2

HCID 78373Dimethylformamide dimethyl acetalHCID 59436251HCID 59436251, compound

Product 1

HCID 71272086HCID 71272086, compound

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

A mixture of 3-acetyl-5-methoxy-1-[2-methoxy-4-(1H-pyrazol-1-yl)phenyl]pyridazin-4(1H)-one (264 mg), N,N-dimethylformamide dimethyl acetal (1.5 mL) and acetonitrile (1.5 mL) was heated under reflux for 3 hr. The reaction mixture was concentrated under reduced pressure, and the residue was crystallized from ethanol to give the title compound (274 mg).

Workup

  1. temperaturewas heated
  2. temperatureunder reflux for 3 hr
  3. concentrationThe reaction mixture was concentrated under reduced pressure
  4. customthe residue was crystallized from ethanol

Sources & evidence

ORD record
ord-51c4a1b0b1f648a386aeca51aa10f87b
Source dataset
uspto-grants-2015_07
Patent number
US09090586B2

Reaction notes

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