反应详情

A mixture of 3-acetyl-5-methoxy-1-[2-methoxy-4-(1H-pyrazol-1-yl)phenyl]pyridazin-4(1H)-one (264 mg), N,N-dimethylformamide dimethyl acetal (1.5 mL) and acetonitrile (1.5 mL) was heated under reflux for 3 hr. The reaction mixture was concentrated under reduced pressure, and the residue was crystallized from ethanol to give the title compound (274 mg).

1. temperaturewas heated
2. temperatureunder reflux for 3 hr
3. concentrationThe reaction mixture was concentrated under reduced pressure
4. customthe residue was crystallized from ethanol