HuagongsheHuagongshe Chemistry Print Report · For research reference only
Trifluoroacetic acid → HCID 71272157, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Trifluoroacetic acid | HCID 6422 | — |
| Reactant | 1-(3-tert-butoxy-4-nitrophenyl)-3,4-difluoro-1H-pyrrole | HCID 71272166 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | HCID 71272157 | HCID 71272157 | 95.6% |
Reaction Steps
A mixture of 1-(3-tert-butoxy-4-nitrophenyl)-3,4-difluoro-1H-pyrrole (8.30 g), TFA (30 mL) and THF (60 mL) was heated under reflux for 3 hr. The reaction mixture was concentrated under reduced pressure, and the residue was washed with hexane/ethyl acetate (10/1) to give the title compound (6.43 g).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09090586B2 |
| Source dataset | uspto-grants-2015_07 |
| ORD ID | ord-1e34f72d86484d31814dadea9f71d325 |
| Source note | uspto-grants-2015_07 |