Trifluoroacetic acid → HCID 71272157, compound

HRID 1528055Notes

Reaction equation

HRID 1528055 reaction equation
C([O:5][C:6]1[CH:7]=[C:8]([N:15]2[CH:19]=[C:18]([F:20])[C:17]([F:21])=[CH:16]2)[CH:9]=[CH:10][C:11]=1[N+:12]([O-:14])=[O:13])(C)(C)C.C(O)(C(F)(F)F)=O>C1COCC1>[F:20][C:18]1[C:17]([F:21])=[CH:16][N:15]([C:8]2[CH:9]=[CH:10][C:11]([N+:12]([O-:14])=[O:13])=[C:6]([OH:5])[CH:7]=2)[CH:19]=1

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 712721661-(3-tert-butoxy-4-nitrophenyl)-3,4-difluoro-1H-pyrrole

Product 1

HCID 71272157HCID 71272157, compoundYield 95.6%

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

A mixture of 1-(3-tert-butoxy-4-nitrophenyl)-3,4-difluoro-1H-pyrrole (8.30 g), TFA (30 mL) and THF (60 mL) was heated under reflux for 3 hr. The reaction mixture was concentrated under reduced pressure, and the residue was washed with hexane/ethyl acetate (10/1) to give the title compound (6.43 g).

Workup

  1. temperaturewas heated
  2. temperatureunder reflux for 3 hr
  3. concentrationThe reaction mixture was concentrated under reduced pressure
  4. washthe residue was washed with hexane/ethyl acetate (10/1)

Sources & evidence

ORD record
ord-1e34f72d86484d31814dadea9f71d325
Source dataset
uspto-grants-2015_07
Patent number
US09090586B2

Reaction notes

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