Dimethylformamide dimethyl acetal → HCID 86686550, compound

HRID 1528058Notes

Reaction equation

HRID 1528058 reaction equation
[CH2:1]([O:8][C:9]1[CH:14]=[C:13]([N:15]2[CH:19]=[C:18]([F:20])[C:17]([F:21])=[CH:16]2)[CH:12]=[CH:11][C:10]=1[NH:22][N:23]=[C:24]([C:29](=[O:33])[CH2:30][O:31][CH3:32])[C:25]([O:27][CH3:28])=[O:26])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[CH3:34]OC(OC)N(C)C>>[CH2:1]([O:8][C:9]1[CH:14]=[C:13]([N:15]2[CH:19]=[C:18]([F:20])[C:17]([F:21])=[CH:16]2)[CH:12]=[CH:11][C:10]=1[N:22]1[CH:34]=[C:30]([O:31][CH3:32])[C:29](=[O:33])[C:24]([C:25]([O:27][CH3:28])=[O:26])=[N:23]1)[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

Participants

3

Reactant 2

HCID 78373Dimethylformamide dimethyl acetalHCID 178496279HCID 178496279, compound

Product 1

HCID 86686550HCID 86686550, compound

Procedure

A mixture of methyl 2-{[2-(benzyloxy)-4-(3,4-difluoro-1H-pyrrol-1-yl)phenyl]hydrazono}-4-methoxy-3-oxobutanoate (4.85 g) and N,N-dimethylformamide dimethyl acetal (100 mL) was heated under reflux for 3 hr. The mixture was allowed to be cooled to room temperature, and the precipitate was collected by filtration, and recrystallized from methanol to give the title compound (4.57 g).

Workup

  1. temperaturewas heated
  2. temperatureunder reflux for 3 hr
  3. filtrationthe precipitate was collected by filtration
  4. customrecrystallized from methanol

Sources & evidence

ORD record
ord-73e61775898445eab5cf791643266ed4
Source dataset
uspto-grants-2015_07
Patent number
US09090586B2

Reaction notes

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