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HRID1528095

反应详情

EQUATION

反应方程式

HRID 1528095 的结构方程式

REACTANTS

反应物

3
结构：CN(C)C=O
HCID6228

N,N-Dimethylformamide

C3H7NO

结构：O=C(Nc1cccc(C2=CCOCC2)n1)Nc1ccnc2c(F)cccc12
HCID57521263

N-[6-(3,6-Dihydro-2H-pyran-4-yl)-2-pyridinyl]-N′-(8-fluoro-4-quinolinyl)urea

C20H17FN4O2

结构：[H][H]
HCID178418361

未命名化合物

PRODUCTS

生成物

1
结构：O=C(Nc1cccc(C2CCOCC2)n1)Nc1ccnc2c(F)cccc12
HCID57409572

未命名化合物

收率 99%

AUXILIARIES

试剂、催化剂与溶剂

3
结构：CC(=O)O
催化剂HCID176

Acetic Acid

C2H4O2

结构：[Pd]
催化剂HCID23938

Palladium

Pd

结构：CO
溶剂HCID887

Methanol

CH4O

PROCEDURE

实验过程

A solution of (1-(6-(3,6-dihydro-2H-pyran-4-yl)pyridin-2-yl)-3-(8-fluoroquinolin-4-yl)urea (21 mg, 0.058 mmol) and 12.3 mg of palladium on charcoal in 20 mL of methanol together with 1 mL of DMF and 1 drop of AcOH was stirred under 1 atm of hydrogen for 18 h. Filtration and evaporation to dryness afforded 21 mg (99%) of the desired title product.

WORKUP

后处理

  1. filtrationFiltration and evaporation to dryness