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温度

0 °C

A solution of methylamine (2 M in methanol) at 0° C. was added dropwise to a solution of 14.82 g of ethyl 2-bromomethyl-6-methoxybenzoate in methanol and the reaction medium was stirred for 5 hours at 0° C. and left to stir at ambient temperature for 2 days. The solvent was evaporated off and 30 ml of a saturated sodium hydrogen carbonate solution were added to the residue. The product was extracted with ethyl acetate (3×50 ml). The organic phases were combined, dried over magnesium sulfate and evaporated. The residue was purified by chromatography on silica gel. 4.52 g of 7-methoxy-2-methyl-2,3-dihydroisoindol-1-one were obtained. Yield=47%.

1. waitleft
2. stirringto stir at ambient temperature for 2 days
3. customThe solvent was evaporated off
4. addition30 ml of a saturated sodium hydrogen carbonate solution were added to the residue
5. extractionThe product was extracted with ethyl acetate (3×50 ml)
6. dry with materialdried over magnesium sulfate
7. customevaporated
8. customThe residue was purified by chromatography on silica gel