反应详情

Tetrabutylammonium fluoride (1 M THF solution, 0.73 mL, 0.73 mmol) was added to an anhydrous tetrahydrofuran (5 mL) solution of (4aS,8aS)-1-(2-cyano-1-(triisopropylsilyl)-1H-indol-5-yl) 3,3-dimethyldecahydroquinoxaline (170 mg, 0.366 mmol) at room temperature, and the reaction solution was stirred at room temperature for 1 hour. The reaction solution was concentrated under reduced pressure, and the obtained residue was purified by basic silica gel column chromatography (AcOEt/hexane= 1/10→ 1/1). The solvent was removed under reduced pressure. The obtained residue was recrystallized from ethyl acetate/n -hexane to obtain (4aS,8aS)-1-(2-cyano-1H-indol-5-yl) 3,3-dimethyldecahydroquinoxaline (30 mg, yield: 27%) in a white powder form.

1. concentrationThe reaction solution was concentrated under reduced pressure
2. customthe obtained residue was purified by basic silica gel column chromatography (AcOEt/hexane= 1/10→ 1/1)
3. customThe solvent was removed under reduced pressure
4. customThe obtained residue was recrystallized from ethyl acetate/n -hexane