反应详情

To a solution of (2Z)-(hydroxyimino)(phenyl)acetonitrile (2.5 g, 17.10 mmol, 1 eq.) in 100 ml of acetonitrile and 10 ml DMF was added 4-(chloromethyl)-1,3-thiazol-2-amine hydrochloride (3.79 g, 20.52 mmol, 1.2 eq.) followed by potassium iodide (283 mg, 1.71 mmol, 0.1 eq.) and caesium carbonate (13.37 g, 41.05 mmol, 2.4 eq.). The reaction was stirred overnight at room temperature. The solvent was then evaporated and the residue dissolved in EtOAc (100 ml). The organic layer was washed with H2O and dried over MgSO4 then concentrated. (2Z)-{[(2-amino-1,3-thiazol-4-yl)methoxy]imino}(phenyl)acetonitrile (4 g, 90% yield, only 1 oxime isomer) was obtained as a white solid.

1. customThe solvent was then evaporated
2. dissolutionthe residue dissolved in EtOAc (100 ml)
3. washThe organic layer was washed with H2O
4. dry with materialdried over MgSO4
5. concentrationthen concentrated