(4-Chloro-3-methylphenyl)boronic acid → 5-(4-Chloro-3-methylphenyl)-6-cyclobutoxynicotinic acid

HRID 1528397Notes

Reaction equation

HRID 1528397 reaction equation
Br[C:2]1[C:3]([O:11][CH:12]2[CH2:15][CH2:14][CH2:13]2)=[N:4][CH:5]=[C:6]([CH:10]=1)[C:7]([OH:9])=[O:8].[Cl:16][C:17]1[CH:22]=[CH:21][C:20](B(O)O)=[CH:19][C:18]=1[CH3:26]>>[Cl:16][C:17]1[CH:22]=[CH:21][C:20]([C:2]2[C:3]([O:11][CH:12]3[CH2:15][CH2:14][CH2:13]3)=[N:4][CH:5]=[C:6]([CH:10]=2)[C:7]([OH:9])=[O:8])=[CH:19][C:18]=1[CH3:26]

Participants

3

Reactant 2

HCID 3786632(4-Chloro-3-methylphenyl)boronic acidHCID 66678843HCID 66678843, compound

Product 1

HCID 666784895-(4-Chloro-3-methylphenyl)-6-cyclobutoxynicotinic acid

Procedure

The title compound was synthesized in analogy to Example BQ using 5-bromo-6-cyclobutoxy-nicotinic acid (example BY) and B-(4-chloro-3-methylphenyl)-boronic acid (CAN 161950-10-3) as starting materials; MS (ESI): 316.2 (M−H)−.

Sources & evidence

ORD record
ord-e569bd2b3a484ebcbc970781d20fd73b
Source dataset
uspto-grants-2015_07
Patent number
US09090599B2

Reaction notes

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