Tetrahydro-3-furanmethanol → 5-(4-Chloro-phenyl)-6-(tetrahydro-furan-3-ylmethoxy)-nicotinic acid

HRID 1528404Notes

Reaction equation

HRID 1528404 reaction equation
Cl[C:2]1[N:7]=[CH:6][C:5]([C:8]([OH:10])=[O:9])=[CH:4][C:3]=1[C:11]1[CH:16]=[CH:15][C:14]([Cl:17])=[CH:13][CH:12]=1.[O:18]1[CH2:22][CH2:21][CH:20]([CH2:23][OH:24])[CH2:19]1>>[Cl:17][C:14]1[CH:15]=[CH:16][C:11]([C:3]2[C:2]([O:24][CH2:23][CH:20]3[CH2:21][CH2:22][O:18][CH2:19]3)=[N:7][CH:6]=[C:5]([CH:4]=2)[C:8]([OH:10])=[O:9])=[CH:12][CH:13]=1

Participants

3

Reactant 2

HCID 139980Tetrahydro-3-furanmethanolHCID 866191836-Chloro-5-(4-chlorophenyl)-3-pyridinecarboxylic acid

Product 1

HCID 666784905-(4-Chloro-phenyl)-6-(tetrahydro-furan-3-ylmethoxy)-nicotinic acid

Procedure

The title compound was synthesized in analogy to Example CI using 6-chloro-5-(4-chlorophenyl)-3-pyridine carboxylic acid (CAN 1012792-56-1) and tetrahydro-3-furanmethanol (CAN 15833-61-1) as starting materials; LC-MS (UV peak area/ESI) 91.6%, 334.0833 (M+H)+.

Sources & evidence

ORD record
ord-b070a593c7a54b4fa88843c35c0ff2f5
Source dataset
uspto-grants-2015_07
Patent number
US09090599B2

Reaction notes

Loading…