(3-Ethyl-1,2-oxazol-5-yl)methanamine → 4-(4-Chloro-phenyl)-5-(2,2,2-trifluoro-ethoxy)-pyridine-2-carboxylic acid (3-ethyl-isoxazol-5-ylmethyl)-amide

HRID 1528407Notes

Reaction equation

HRID 1528407 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[C:13]([O:14][CH2:15][C:16]([F:19])([F:18])[F:17])=[CH:12][N:11]=[C:10]([C:20]([OH:22])=O)[CH:9]=2)=[CH:4][CH:3]=1.[CH2:23]([C:25]1[CH:29]=[C:28]([CH2:30][NH2:31])[O:27][N:26]=1)[CH3:24]>>[CH2:23]([C:25]1[CH:29]=[C:28]([CH2:30][NH:31][C:20]([C:10]2[CH:9]=[C:8]([C:5]3[CH:4]=[CH:3][C:2]([Cl:1])=[CH:7][CH:6]=3)[C:13]([O:14][CH2:15][C:16]([F:19])([F:17])[F:18])=[CH:12][N:11]=2)=[O:22])[O:27][N:26]=1)[CH3:24]

Participants

3

Reactant 2

HCID 6483891(3-Ethyl-1,2-oxazol-5-yl)methanamineHCID 66687043HCID 66687043, compound

Product 1

HCID 569296594-(4-Chloro-phenyl)-5-(2,2,2-trifluoro-ethoxy)-pyridine-2-carboxylic acid (3-ethyl-isoxazol-5-ylmethyl)-amide

Procedure

The title compound was synthesized in analogy to Example 1, using 4-(4-chloro-phenyl)-5-(2,2,2-trifluoro-ethoxy)-pyridine-2-carboxylic acid (example D) and 3-ethyl-5-isoxazolemethanamine as starting materials; LC-MS (UV peak area/ESI) 100%, 440.0985 (M+H)+.

Sources & evidence

ORD record
ord-4d2f74f7d8c64ac1a6662b7521a5258a
Source dataset
uspto-grants-2015_07
Patent number
US09090599B2

Reaction notes

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