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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1528407Generated: November 3, 2026

(3-Ethyl-1,2-oxazol-5-yl)methanamine → 4-(4-Chloro-phenyl)-5-(2,2,2-trifluoro-ethoxy)-pyridine-2-carboxylic acid (3-ethyl-isoxazol-5-ylmethyl)-amide

https://huagongshe.com/reaction/1528407

Reaction equation

Participants

RoleNameHCIDCharge
Reactant(3-Ethyl-1,2-oxazol-5-yl)methanamineHCID 6483891—
ReactantHCID 66687043HCID 66687043—
Product4-(4-Chloro-phenyl)-5-(2,2,2-trifluoro-ethoxy)-pyridine-2-carboxylic acid (3-ethyl-isoxazol-5-ylmethyl)-amideHCID 56929659—

Reaction Steps

The title compound was synthesized in analogy to Example 1, using 4-(4-chloro-phenyl)-5-(2,2,2-trifluoro-ethoxy)-pyridine-2-carboxylic acid (example D) and 3-ethyl-5-isoxazolemethanamine as starting materials; LC-MS (UV peak area/ESI) 100%, 440.0985 (M+H)+.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS09090599B2
Source datasetuspto-grants-2015_07
ORD IDord-4d2f74f7d8c64ac1a6662b7521a5258a
Source noteuspto-grants-2015_07